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Article

IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA.

The Journal of biological chemistry - 26 Dec 2008

Mortimer Sarah E, Xu Dong, McGrew Dharia, Hamaguchi Nobuko, Lim Hoong Chuin, Bowne Sara J, Daiger Stephen P, Hedstrom Lizbeth

Abstract excerpt

IMP dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. Here we show that both IMPDH type 1 (IMPDH1) and IMPDH type 2 are associated with polyribosomes, suggesting that these housekeeping proteins have an unanticipated role in translation regulation. This interact...

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Identifiers

PMID: 18974094
DOI: 10.1074/jbc.M806143200
PMCID: PMC2605994

Genes

IMPDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18974094-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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