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Article

Role of lysine-67 in the active site of class C beta-lactamase from Citrobacter freundii GN346.

European journal of biochemistry - 22 Feb 1990

Tsukamoto K, Tachibana K, Yamazaki N, Ishii Y, Ujiie K, Nishida N, Sawai T

Abstract excerpt

Citrobacter freundii GN346 produces a class C beta-lactamase exhibiting the substrate profile of a typical cephalosporinase. The structural and promoter regions of the cephalosporinase gene, comprising 1408 nucleotides, were completely sequenced. The amino acid sequence of the mature enzyme, comprising 361 amino acids, and its molecular mass, 39,878 Da, were determined. The active site was confirmed to be Ser-64....

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Identifiers

PMID: 1969344
DOI: 10.1111/j.1432-1033.1990.tb15365.x

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