Article
Resistance to oxyimino beta-lactams due to a mutation of chromosomal beta-lactamase in Citrobacter freundii.
Microbiology and immunology - 1 Jan 1998
Haruta S, Nukaga M, Taniguchi K, Sawai T
Abstract excerpt
The duplicative mutation of an Ala-Val-Arg sequence at positions 208 to 210 in the loop structure of Enterobacter cloacae class C beta-lactamase caused substrate specificity extension to oxyimino beta-lactam antibiotics and this chromosomal mutation provided bacterial cells with high resistance t...
Topics
- Amino Acid Sequence
- Cephalosporin Resistance
- Citrobacter freundii
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Penicillin Resistance
- Sequence Homology, Amino Acid
- Substrate Specificity
- beta-Lactam Resistance
- beta-Lactamases