Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of CDKN2A gene in a group of 390 larynx cancer patients.

Molecular biology reports - 1 Jan 2010

Kiwerska Katarzyna, Rydzanicz Małgorzata, Kram Andrzej, Pastok Martyna, Antkowiak Agata, Domagała Wenancjusz, Szyfter Krzysztof

Abstract excerpt

CDKN2A gene belongs to the genes involved in cell cycle regulation. When is absent or inactivated by mutation or promoter hypermethylation a cell may undertake an uncontrolled proliferation. Inactivation of CDKN2A gene is observed in many human malignancies, including larynx cancer. In this study we investigated mutations in exon 1 and exon 2 of CDKN2A gene in a large group of 390 laryngeal cancers. We found 40...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Introns

Share to Laryngeal Neoplasms

Share to Open Reading Frames

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 19690981
DOI: 10.1007/s11033-009-9731-z

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of CDKN2A gene in a group of 390 larynx cancer patients.PMID 19690981Read ↗

Mutational Status of CDKN2A and TP53 Genes in Laryngeal Squamous Cell Carcinoma.Semantic proximity Read ↗

The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3' UTR, and their association with clinical course of melanoma.Semantic proximity Read ↗

A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare.Semantic proximity Read ↗

Novel CDKN2A mutations detected in western Swedish families with hereditary malignant melanoma.Semantic proximity Read ↗

Tumor suppressor gene p16 (CDKN2A) mutation status and promoter inactivation in head and neck cancer.Semantic proximity Read ↗

Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A gene.Semantic proximity Read ↗

Cyclin D1 gene (CCND1) polymorphism and the risk of squamous cell carcinoma of the larynx.Semantic proximity Read ↗

Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer.Semantic proximity Read ↗

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.Semantic proximity Read ↗

Absence of the L37P polymorphism in exon 1 of the CDKN2A gene.Semantic proximity Read ↗

Mutation rate of the CDKN2 gene in malignant gliomas.Semantic proximity Read ↗

Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.