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Article

Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer.

PloS one - 1 Jan 2022

Ullah Farman, Khurshid Nadia, Fatimi Qaiser, Loidl Peter, Saeed Muhammad

Abstract excerpt

Retinoblastoma like protein-2 (Rbl2) is functionally regulated by phosphorylation and acetylation. Previously, we demonstrated that lysine K1083 (K1079 in human Rbl2) is a potential target for acetylation but its functional role remains elusive. We investigated alterations in human Rbl2 gene specifically targeting exons 19-22 harbouring acetylatable residues i.e. K1072, K1083 and K1115 through single stranded...

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Identifiers

PMID: 35385527
DOI: 10.1371/journal.pone.0266196
PMCID: PMC8985964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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