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Article

Increased expression of class III β-tubulin in castration-resistant human prostate cancer

18 Aug 2009

Abstract excerpt

BACKGROUND: Class III beta-tubulin (betaIII-tubulin) is expressed in tissues of neuronal lineage and also in several human malignancies, including non-small-cell lung carcinoma, breast and ovarian cancer. Overexpression of betaIII-tubulin in these tumours is associated with an unfavourable outcome and resistance to taxane-based therapies. At present, betaIII-tubulin expression remains largely uncharacterised in...

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PMID: 19690549
DOI: 10.1038/sj.bjc.6605245

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