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Article

βIII-tubulin overexpression is an independent predictor of prostate cancer progression tightly linked to ERG fusion status and PTEN deletion.

The American journal of pathology - 1 Mar 2014

Tsourlakis Maria C, Weigand Philipp, Grupp Katharina, Kluth Martina, Steurer Stefan, Schlomm Thorsten, Graefen Markus, Huland Hartwig, Salomon Georg, Steuber Thomas, Wilczak Waldemar, Sirma Hüseyin, Simon Ronald, Sauter Guido, Minner Sarah, Quaas Alexander

Abstract excerpt

Evidence suggests that class III β-tubulin (βIII-tubulin) may represent a prognostic and predictive molecular marker in prostate cancer. βIII-Tubulin expression was determined by IHC in 8179 prostate cancer specimens in a TMA format. Results were compared with tumor phenotype, biochemical recurrence, v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) status, and deletions on PTEN, 3p13, 5q21, and 6q15....

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Topics

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Share to Neoplasm Grading
Share to Oncogene Proteins, Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prostate-Specific Antigen

Share to Prostatectomy

Share to PTEN Phosphohydrolase

Share to Tissue Array Analysis

Share to Transcriptional Regulator ERG

Share to Tubulin

Source

Identifiers

PMID: 24378408
DOI: 10.1016/j.ajpath.2013.11.007

Genes

ERG
PTEN
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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