Article
Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.
Cancer research - 1 Sept 2009
Lu Kan V, Zhu Shaojun, Cvrljevic Anna, Huang Tiffany T, Sarkaria Shawn, Ahkavan David, Dang Julie, Dinca Eduard B, Plaisier Seema B, Oderberg Isaac, Lee Yohan, Chen Zugen, Caldwell Jeremy S, Xie Yongmin, Loo Joseph A, Seligson David, Chakravari Arnab, Lee Francis Y, Weinmann Roberto, Cloughesy Timothy F, Nelson Stanley F, Bergers Gabriele, Graeber Thomas, Furnari Frank B, James C David, Cavenee Webster K, Johns Terrance G, Mischel Paul S
Abstract excerpt
Activating epidermal growth factor receptor (EGFR) mutations are common in many cancers including glioblastoma. However, clinical responses to EGFR inhibitors are infrequent and short-lived. We show that the Src family kinases (SFK) Fyn and Src are effectors of oncogenic EGFR signaling, enhancing invasion and tumor cell survival in vivo. Expression of a constitutively active EGFR mutant, EGFRvIII, resulted in...
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