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Article

Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jul 2007

Vazquez Roque Maria I, Camilleri Michael, Clark Matthew M, Tepoel Debra A, Jensen Michael D, Graszer Karen M, Kalsy Sarah A, Burton Duane D, Baxter Kari L, Zinsmeister Alan R

Abstract excerpt

BACKGROUND & AIMS: It is unclear whether weight loss with the noradrenergic (norepinephrine) and serotonergic (5-hydroxytryptamine) reuptake inhibitor, sibutramine, is associated with altered stomach functions and whether genetics influence treatment response. METHODS: Forty-eight overweight and obese but otherwise healthy participants were randomized to placebo or sibutramine (15 mg/day for 12 weeks). At...

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PMID: 17544870
DOI: 10.1016/j.cgh.2007.02.037

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