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Article

Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism.

Pharmacogenetics - 1 Aug 2003

Hauner Hans, Meier Marion, Jöckel Karl-Heinz, Frey Ulrich H, Siffert Winfried

Abstract excerpt

BACKGROUND: Sibutramine, a centrally acting noradrenaline and serotonin re-uptake inhibitor, enhances satiety and is frequently used to support weight loss. However, a significant variability exists among individuals concerning the response to sibutramine. METHODS: We genotyped 111 participants o...

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Source

Identifiers

PMID: 12893983
DOI: 10.1097/00008571-200308000-00003

Genes

GNB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12893983-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism.PMID 12893983Read ↗

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Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine.Semantic proximity Read ↗

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