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Article

KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2.

Cell adhesion & migration - 1 Dec 2020

Sun Lan, Zhou Xiaona, Li Yanmeng, Chen Wei, Wu Shanna, Zhang Bei, Yao Jingyi, Xu Anjian

Abstract excerpt

Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tumor antigen p53 (p53). Furthermore, zinc finger E-box-binding homeobox 2 (ZEB2) is the main regulator of KLF5 in EMT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32965165
DOI: 10.1080/19336918.2020.1826216
PMCID: PMC7553557

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