Article

Computational modelling of novelty detection in the mismatch negativity protocols and its impairments in schizophrenia

2025-10-01

Abstract excerpt

The human auditory system rapidly distinguishes between novel and familiar sounds, a process reflected in mismatch negativity (MMN), an EEG-based biomarker of auditory novelty detection. MMN is impaired in psychiatric conditions, most notably schizophrenia (SCZ), yet the neuronal mechanisms underlying this deficit remain unclear. Here, we combined computational modelling and genetic analyses to investigate how SCZ...

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Literature Corpus work: cf039bd9-6b91-53de-a74f-795facb8dc31
DOI: 10.1101/2025.09.30.679453

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