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Article

Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.

Cell death and differentiation - 1 Oct 2010

Nisoli I, Chauvin J P, Napoletano F, Calamita P, Zanin V, Fanto M, Charroux B

Abstract excerpt

Polyglutamine pathologies are neurodegenerative diseases that manifest both general polyglutamine toxicity and mutant protein-specific effects. Dentatorubral-pallidoluysian Atrophy (DRPLA) is one of these disorders caused by mutations in the Atrophin-1 protein. We have generated several models for DRPLA in Drosophila and analysed the mechanisms of cellular and organism toxicity. Our genetic and ultrastructural...

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Identifiers

PMID: 20339376
DOI: 10.1038/cdd.2010.31

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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