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Article

Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.

The Journal of biological chemistry - 5 May 2006

Ying Mingyao, Xu Rener, Wu Xiaohui, Zhu Huaxing, Zhuang Yuan, Han Min, Xu Tian

Abstract excerpt

Dentatorubral-pallidoluysian atrophy (DRPLA) is a progressive neurodegenerative disease caused by polyglutamine expansion within the Atrophin-1 protein. To study the mechanism of this disease and to test potential therapeutic methods, we established Atro-118Q transgenic mice, which express in neu...

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Identifiers

PMID: 16407196
DOI: 10.1074/jbc.M511677200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16407196-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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