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Article

Microtubule‐associated protein tau in human prostate cancer cells: Isoforms, phosphorylation, and interactions

13 Aug 2009

Abstract excerpt

Tau is a microtubule-associated protein whose function has been investigated primarily in neurons. Recently, tau expression has been correlated with increased drug resistance in various cancers of non-neuronal tissues. In this report, we investigate the tau expressed in cancerous prostate lines ALVA-31, DU 145, and PC-3. Prostate cancer tau is heat-stable and highly phosphorylated, containing many of the...

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PMID: 19681044
DOI: 10.1002/jcb.22287

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