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Article

Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma

10 Apr 2025

Abstract excerpt

BACKGROUND: Immunotherapy targeting the programmed death-ligand 1 (PD-L1) pathway is a standard treatment for advanced hepatocellular carcinoma (HCC). The Wnt signaling pathway, often upregulated in HCC, contributes to an immunosuppressive tumor microenvironment. This study investigated the impact of Wnt pathway inhibition on PD-L1 expression in HCC and evaluated the potential therapeutic benefit of combining Wnt...

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Share to Cancer Immunotherapy and Biomarkers
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PMID: 40211365
DOI: 10.1186/s13062-025-00645-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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