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Article

Aggressive inherited and sporadic medullary thyroid carcinomas display similar oncogenic pathways.

Endocrine-related cancer - 1 Dec 2009

Ameur Nabahet, Lacroix Ludovic, Roucan Sophie, Roux Véronique, Broutin Sophie, Talbot Monique, Dupuy Corinne, Caillou Bernard, Schlumberger Martin, Bidart Jean-Michel

Abstract excerpt

RET oncogene mutations are found in familial medullary thyroid carcinomas (MTC) and in one-third of sporadic cases. Oncogenic mechanisms involved in non-RET mutated sporadic MTC remain unclear. To study alterations associated with the development of both inherited and sporadic MTC, pangenomic DNA microarrays were used to analyze the transcriptome of 13 MTCs (four familial and nine sporadic). By using an ANOVA...

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Topics

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Share to Carcinoma, Medullary
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Oligonucleotide Array Sequence Analysis

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Share to Proto-Oncogene Proteins c-ret

Share to RNA, Small Interfering

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Source

Identifiers

PMID: 19675075
DOI: 10.1677/ERC-08-0289

Genes

PTN
RET
CEACAM6
ESM1
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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