Article
Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens.
Lancet (London, England) - 20 Jan 1990
Voogt P J, Fibbe W E, Marijt W A, Goulmy E, Veenhof W F, Hamilton M, Brand A, Zwann F E, Willemze R, van Rood J J
Abstract excerpt
A female patient showed rejection of a T-lymphocyte-depleted bone-marrow graft from her phenotypically HLA-identical father. Before bone-marrow transplantation, there was strong recipient anti-donor cellular cytotoxic reactivity directed against several minor histocompatibility (mH) antigens, inc...
Topics
- Adult
- Bone Marrow Transplantation
- Cell Line
- Chromosome Mapping
- Evaluation Studies as Topic
- Female
- Graft Rejection
- H-Y Antigen
- HLA Antigens
- Hematopoietic Stem Cells
- Humans
- Lymphocyte Depletion
- Male
- Metaphase
- Myelodysplastic Syndromes