Article
Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens.
Lancet (London, England) - 20 Jan 1990
Voogt P J, Fibbe W E, Marijt W A, Goulmy E, Veenhof W F, Hamilton M, Brand A, Zwann F E, Willemze R, van Rood J J
Abstract excerpt
A female patient showed rejection of a T-lymphocyte-depleted bone-marrow graft from her phenotypically HLA-identical father. Before bone-marrow transplantation, there was strong recipient anti-donor cellular cytotoxic reactivity directed against several minor histocompatibility (mH) antigens, including the male-specific H-Y antigen. After conditioning treatment, no recipient anti-donor cytotoxic activity could be...
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