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The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

24 Nov 2017

Abstract excerpt

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell proliferation, differentiation, cell survival, senescence, DNA damage repair and cell cycle control. The development of resistance to both conventional and newly emerged molecularly targeted therapies is a major challenge confronting current...

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PMID: 29180117
DOI: 10.1016/j.semcancer.2017.11.018

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