Article
Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression.
Trials - 11 Aug 2009
Knorr Ulla, Vinberg Maj, Klose Marianne, Feldt-Rasmussen Ulla, Hilsted Linda, Gade Anders, Haastrup Eva, Paulson Olaf, Wetterslev Jørn, Gluud Christian, Gether Ulrik, Kessing Lars
Abstract excerpt
BACKGROUND: Endophenotypes are heritable markers, which are more prevalent in patients and their healthy relatives than in the general population. Recent studies point at disturbed regulation of the hypothalamic-pituitary-adrenocortical axis as a possible endophenotype for depression. We hypothesize that potential endophenotypes for depression may be affected by selective serotonin re-uptake inhibitor...
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