Article
Discovering endophenotypes for major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2004
Hasler Gregor, Drevets Wayne C, Manji Husseini K, Charney Dennis S
Abstract excerpt
The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow definitions of putative psychopathological endophenotypes:...
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