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Article

Addiction to protein kinase CK2: a common denominator of diverse cancer cells?

Biochimica et biophysica acta - 1 Mar 2010

Ruzzene Maria, Pinna Lorenzo A

Abstract excerpt

At variance with most oncogenic protein kinases whose malignancy is generally due to genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein kinase naturally endowed with constitutive activity and lacking gain-of-function mutants. Nonetheless CK2 is abnormally elevated in a wide variety of tumors and there is strong evidence that it operates as a cancer driver by creating...

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Identifiers

PMID: 19665589
DOI: 10.1016/j.bbapap.2009.07.018

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