Article
Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
The Plant cell - 1 Jan 2018
Li Baohua, Tang Michelle, Nelson Ayla, Caligagan Hart, Zhou Xue, Clark-Wiest Caitlin, Ngo Richard, Brady Siobhan M, Kliebenstein Daniel J
Abstract excerpt
Plants use diverse mechanisms influenced by vast regulatory networks of indefinite scale to adapt to their environment. These regulatory networks have an unknown potential for epistasis between genes within and across networks. To test for epistasis within an adaptive trait genetic network, we generated and tested 47 Arabidopsis thaliana double mutant combinations for 20 transcription factors, which all influence...
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