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Article

Ross River virus variants selected during passage in chick embryo fibroblasts: serological, genetic, and biological changes.

Virology - 1 Mar 1993

Kerr P J, Weir R C, Dalgarno L

Abstract excerpt

Serial passage of Ross River virus in chick embryo fibroblasts selected for virus variants altered in their reactions to neutralizing monoclonal antibodies. The E1 and E2 genes of each antigenic variant were sequenced; single nucleotide changes were found in E2 leading to amino acid substitutions at either residue 4 (Glu-->Lys) or 218 (Asn-->Lys); no changes were found in the E1 gene. Variants with the...

Topics

Animals
Cell Line
Chick Embryo
Culicidae
Epitopes
Fibroblasts
Genes, Viral
Genetic Variation
Humans
Mice
Ross River virus
Serial Passage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Envelope Proteins

Source

Identifiers

PMID: 7679860
DOI: 10.1006/viro.1993.1143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7679860-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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