Article
Amino acid and phenotypic changes in dengue 2 virus associated with escape from neutralisation by IgM antibody.
Journal of medical virology - 1 Oct 2001
Lok S M, Ng M L, Aaskov J
Abstract excerpt
Two dengue 2-specific IgM monoclonal antibodies (MAb) recognised spatially unrelated epitopes on the envelope (E) protein of dengue 2 virus, which were also recognised by serum from 20 and 50%, respectively, of patients with a primary dengue 2 infection. Dengue 2 virus populations escaping neutralisation by MAb 6B2 (representing the majority population of dengue 2-specific IgM MAbs ) had a deduced amino acid...
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