Article
Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.
Anticancer research - 1 Aug 2009
Vaziri Susan A J, Grabowski Dale R, Hill Jason, Rybicki Lisa R, Burk Robert, Bukowski Ronald M, Ganapathi Mahrukh K, Ganapathi Ram
Abstract excerpt
BACKGROUND: Antiproliferative effects of proteasome inhibitors are suggested to be primarily due to effects on nuclear factor-kappaB (NF-kappaB)-dependent pathways and the induction of apoptosis. The objective of this study was to elucidate the mechanistic basis for the antiproliferative effects of the proteasome inhibitor, bortezomib, in human clear cell renal cell cancer cells (CCRCC). MATERIALS AND METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.