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Article

IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2009

Wang Yang, Chaudhri Geeta, Jackson Ronald J, Karupiah Gunasegaran

Abstract excerpt

A strong cell-mediated immune response is critical for controlling viral infections and is regulated by a number of cytokines, including IL-12 and IL-18. Indeed, some viruses have evolved to specifically target these pathways to counter the host immune response. Orthopoxviruses, including ectromelia virus, encode immune evasion molecules that specifically target IL-18 and IFN-gamma. We hypothesized that IL-12 and...

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Share to Cytotoxicity, Immunologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-12 Subunit p40

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Source

Identifiers

PMID: 19657092
DOI: 10.4049/jimmunol.0803985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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