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Article

Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.

Diabetes - 1 Nov 2009

Bonnefond Amélie, Vaxillaire Martine, Labrune Yann, Lecoeur Cécile, Chèvre Jean-Claude, Bouatia-Naji Nabila, Cauchi Stéphane, Balkau Beverley, Marre Michel, Tichet Jean, Riveline Jean-Pierre, Hadjadj Samy, Gallois Yves, Czernichow Sébastien, Hercberg Serge, Kaakinen Marika, Wiesner Susanne, Charpentier Guillaume, Lévy-Marchal Claire, Elliott Paul, Jarvelin Marjo-Riitta, Horber Fritz, Dina Christian, Pedersen Oluf, Sladek Robert, Meyre David, Froguel Philippe

Abstract excerpt

OBJECTIVE: A1C is widely considered the gold standard for monitoring effective blood glucose levels. Recently, a genome-wide association study reported an association between A1C and rs7072268 within HK1 (encoding hexokinase 1), which catalyzes the first step of glycolysis. HK1 deficiency in erythrocytes (red blood cells [RBCs]) causes severe nonspherocytic hemolytic anemia in both humans and mice. RESEARCH...

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Identifiers

PMID: 19651813
DOI: 10.2337/db09-0652
PMCID: PMC2768183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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