Article
Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary.
Development (Cambridge, England) - 1 Feb 2000
Dobens L L, Peterson J S, Treisman J, Raftery L A
Abstract excerpt
The Drosophila BMP homolog DPP can function as a morphogen, inducing multiple cell fates across a developmental field. However, it is unknown how graded levels of extracellular DPP are interpreted to organize a sharp boundary between different fates. Here we show that opposing DPP and EGF signals set the boundary for an ovarian follicle cell fate. First, DPP regulates gene expression in the follicle cells that...
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