Article
Sequence diversity of hepatitis C viral genomes.
Molecular biology & medicine - 1 Dec 1990
Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K
Abstract excerpt
The nucleotide sequences of cDNAs (275 base-pairs) in the non-structural protein 5 regions of Japanese isolates of hepatitis C virus (HCV-J) from the plasma of 11 patients with non-A, non-B hepatitis and the livers of five patients with hepatocellular carcinoma were analyzed. Approximately 14 to 17% of nucleotide sequences of the HCV-Js examined differed from that of the original isolate in the United States...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA
- DNA, Single-Stranded
- Genetic Variation
- Hepacivirus
- Humans
- Liver
- Molecular Sequence Data
- Mutagenesis
- Polymerase Chain Reaction
