Article
cDNA clones of Japanese hepatitis C virus genomes derived from a single patient show sequence heterogeneity.
The Journal of general virology - 1 Nov 1991
Oshima M, Tsuchiya M, Yagasaki M, Orita T, Hasegawa M, Tomonoh K, Kojima T, Hirata Y, Yamamoto O, Sho Y
Abstract excerpt
Twelve cDNA clones of Japanese hepatitis C virus (HCV) have been isolated from liver tissue of a single non-A, non-B hepatitis patient. These clones represented the non-structural domains of HCV. The degree of substitution in the nucleotide sequences and deduced amino acid sequences between these...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA, Viral
- Genes, Viral
- Genetic Variation
- Genomic Library
- Hepacivirus
- Hepatitis C
- Humans
- Japan
- Liver
