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Article

The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells.

Investigational new drugs - 1 Oct 2010

Mason Sharon A, Cozzi Sarah-Jane, Pierce Carly J, Pavey Sandra J, Parsons Peter G, Boyle Glen M

Abstract excerpt

We previously identified the induction of senescence in melanoma cell lines sensitive to diterpene esters, indicating a therapeutic potential. Here we compared the cytostatic effects of two diterpene esters: the prototypic PKC-activating drug TPA (12-O-tetradecanoylphorbol-13-acetate), and the novel compound PEP008 (20-O-acetyl-ingenol-3-angelate) in cell lines derived from melanoma, breast cancer and colon...

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PMID: 19636513
DOI: 10.1007/s10637-009-9292-y

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PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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