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Article

Cell-specific pattern of berberine pleiotropic effects on different human cell lines

9 Jul 2018

Abstract excerpt

The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibroblasts (HDF) were used as non-cancer cells. We show that berberine differentially affects cell...

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PMID: 30006630
DOI: 10.1038/s41598-018-28952-3

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