Article
Gene homogeneity for aminoglycoside-modifying enzymes in gram-positive cocci.
Antimicrobial agents and chemotherapy - 1 Nov 1990
Ounissi H, Derlot E, Carlier C, Courvalin P
Abstract excerpt
Aminoglycoside-resistant strains of Staphylococcus and Enterococcus, approximately 500 of each, were screened by dot blot hybridization for the presence of genes encoding aminoglycoside-modifying enzymes. The MICs of various aminoglycosides for the strains were determined, and the enzyme contents of the cells were inferred from the resistance phenotypes. The agreements (in percent) of the hybridization results...
Topics
- Acetyltransferases
- Aminoglycosides
- Anti-Bacterial Agents
- DNA Probes
- DNA, Bacterial
- Drug Resistance, Microbial
- France
- Kanamycin Kinase
- Nucleic Acid Hybridization
- Nucleotidyltransferases
- Phenotype