Article
CHOP 5'UTR-c.279T>C and +nt30C>T variants are not associated with overweight condition or with tumors/cancer in Italians - a case-control study.
Journal of experimental & clinical cancer research : CR - 26 Jun 2009
Meenakshisundaram Ramachandran, Piumelli Nunzia, Pierpaoli Laura, Gragnoli Claudia
Abstract excerpt
BACKGROUND: Type 2 diabetes (T2D) is associated with obesity and has been shown recently to be associated with tumors/cancer. HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. We have previously shown that CHOP 5'UTR-c.279T>C and +nt30C>T haplotype variants contribute to T2D. CHOP deficiency causes obesity in mice, thus CHOP gene variants may contribute to human obesity. Furthermore, CHOP...
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