CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study.

Abstract excerpt

BACKGROUND: Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at identifying a role of CDK4 IVS4-nt40 G-->A gene variant in benign and/or malignant tumors and in...

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