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Phenotyping psychosis: room for neurocomputational and content-dependent cognitive endophenotypes?

Cognitive neuropsychiatry - 1 Jan 2009

Chen Eric Y H, Wong Gloria H Y, Hui Christy L M, Tang Jennifer Y M, Chiu Cindy P Y, Lam May M L, Sham P C

Abstract excerpt

INTRODUCTION: The endophenotype research strategy aims at reducing complex clinical phenomena to reveal a more tractable mapping to underlying genes. Cognitive dysfunctions have been widely pursued as target endophenotype in schizophrenia. We critically discuss the promise and limitations of this approach. METHODS: Relevant theoretical and empirical issues on genes and behaviour, neurocognitive structure and...

Topics

Cognition
Computational Biology
Genotype
Humans
Mental Disorders
Neurology
Phenotype
Psychotic Disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19634039
DOI: 10.1080/13546800902965695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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