Infertility in male transgenic mice: disruption of sperm development by HSV-tk expression in postmeiotic germ cells.

doi:10.1095/biolreprod43.4.684

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Article

Infertility in male transgenic mice: disruption of sperm development by HSV-tk expression in postmeiotic germ cells.

Biology of reproduction - 1 Oct 1990

Braun R E, Lo D, Pinkert C A, Widera G, Flavell R A, Palmiter R D, Brinster R L

Abstract excerpt

Previous experiments revealed that male transgenic mice bearing a cosmid that included the Class II E alpha gene, about 35 kb of 5' flanking DNA, and the cosmid vector sequences were sterile. To ascertain the cause of the sterility, various subfragments of the cosmid were tested in transgenic mice. Only those pieces of DNA that included some of the E alpha flanking chromosomal DNA and the herpes simplex virus...

Topics

Animals
Chromosome Mapping
Cloning, Molecular
Cosmids
Female
Gene Expression
Genetic Vectors
Infertility, Male
Male
Meiosis
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protamines

Simplexvirus

Spermatogenesis

Spermatozoa

Testis

Source

Open in PubMed

Identifiers

PMID: 1963095
DOI: 10.1095/biolreprod43.4.684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1963095-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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