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Article

Impairment of Spermatogenesis in Transgenic Mice With Selective Overexpression of Bcl‐2 in the Somatic Cells of the Testis

12 Nov 2001

Abstract excerpt

To explore the functional role of Bcl-2 in germ cell development, transgenic mice carrying 6 kilobases of the inhibin-alpha promoter were generated to express human bcl-2 gene product in the gonads. Although female transgenic mice demonstrated decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis, the adult males exhibited variable impairment of spermatogenesis. The degree...

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Identifiers

PMID: 11700863
DOI: 10.1002/j.1939-4640.2001.tb03439.x

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