Article
Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer's Mice and in Human Patients.
Current Alzheimer research - 1 Jan 2015
Plagg Barbara, Ehrlich Daniela, Kniewallner Kathrin M, Marksteiner Josef, Humpel Christian
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-β (Aβ) plaque formation, tau pathology, neurodegeneration and inflammatory processes. Monocytes are involved in inflammation in AD and are recruited to the diseased brain. Recently it has been shown that aberrant epigenetic processes including acetylation are associated with the development of AD. The aim of the present...
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