Article
Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 2009
Inagaki Takeshi, Tachibana Makoto, Magoori Kenta, Kudo Hiromi, Tanaka Toshiya, Okamura Masashi, Naito Makoto, Kodama Tatsuhiko, Shinkai Yoichi, Sakai Juro
Abstract excerpt
Histone H3 lysine 9 (H3K9) methylation is a crucial epigenetic mark of heterochromatin formation and transcriptional silencing. Recent studies demonstrated that most covalent histone lysine modifications are reversible and the jumonji C (JmjC)-domain-containing proteins have been shown to possess...
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