Article
Loss-of-function analyses of the fragile X-related and dopamine receptor genes by RNA interference in the cricket Gryllus bimaculatus.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2009
Hamada Aska, Miyawaki Katsuyuki, Honda-sumi Eri, Tomioka Kenji, Mito Taro, Ohuchi Hideyo, Noji Sumihare
Abstract excerpt
In order to explore a possibility that the cricket Gryllus bimaculatus would be a useful model to unveil molecular mechanisms of human diseases, we performed loss-of-function analyses of Gryllus genes homologous to human genes that are responsible for human disorders, fragile X mental retardation 1 (fmr1) and Dopamine receptor (DopR). We cloned cDNAs of their Gryllus homologues, Gb'fmr1, Gb'DopRI, and Gb'DopRII,...
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