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Article

The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia.

European journal of haematology - 1 Dec 2009

Eliopoulos Dimitrios G, Mavroudi Irene, Pontikoglou Charalampos, Ximeri Maria, Stavroulaki Emily, Pyrovolaki Katerina, Velegraki Maria, Spanoudakis Michael, Goulielmos George, Papadaki Helen A

Abstract excerpt

OBJECTIVE: Impaired granulopoiesis in chronic idiopathic neutropenia (CIN) has been associated with an inflammatory bone marrow (BM) microenvironment consisting of pro-inflammatory and pro-apoptotic mediators, such as tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1, and Fas-Ligand (Fas-L). In this study, we evaluated the frequency of TNF-alpha, TGF-beta1 and Fas-L gene polymorphisms in...

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PMID: 19614955
DOI: 10.1111/j.1600-0609.2009.01319.x

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TNF

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