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Article

Chronic idiopathic neutropenias and severe congenital neutropenia

1 Jan 2008

Abstract excerpt

PURPOSE OF REVIEW: Chronic idiopathic and severe congenital neutropenias are rare disorders for which recent discoveries have highlighted mechanisms and consequences. RECENT FINDINGS: An inflammatory bone marrow milieu has been shown to be a major contributor to the pathophysiology of chronic idiopathic neutropenia. Activated T-lymphocytes with myelosuppressive properties and pro-apoptotic mediators, such as...

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PMID: 18043240
DOI: 10.1097/moh.0b013e3282f172d3

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