Article
Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-β1.
Stem cells and development - 1 Aug 2011
Stavroulaki Emily, Kastrinaki Maria-Christina, Pontikoglou Charalampos, Eliopoulos Dimitrios, Damianaki Athina, Mavroudi Irene, Pyrovolaki Katerina, Katonis Pavlos, Papadaki Helen A
Abstract excerpt
Chronic idiopathic neutropenia (CIN) is a granulopoiesis disorder associated with an inhibitory bone marrow (BM) microenvironment consisting of activated T-lymphocytes and pro-inflammatory mediators. In this study, we investigated the possible involvement of BM mesenchymal stem cells (MSCs) in the pathophysiology of CIN by assessing the frequency and function of BM MSCs in terms of the proliferative/clonogenic...
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