Article
Uterine leiomyoma is associated with a polymorphism in the interleukin 1-beta gene.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Aug 2009
Pietrowski Detlef, Thewes Roberta, Sator Michael, Denschlag Dominik, Keck Christoph, Tempfer Clemens
Abstract excerpt
PROBLEM: To investigate whether polymorphisms in the interleukin-1beta (IL-1beta) gene are associated with uterine leiomyoma. METHOD OF STUDY: Case-control study in a collective of 131 patients and 280 controls. Genotyping of the IL-1beta-511 and IL-1beta-3954 polymorphism was performed by PCR amplification and subsequent RFLP analysis. RESULTS: A significant difference in the allele frequencies of the...
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