Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3'-UTR 2767, and IL-18 105, are associated with higher susceptibility to leiomyoma.

Abstract excerpt

OBJECTIVE: To investigate whether certain polymorphisms are correlated with leiomyoma susceptibility, i.e., interleukin (IL)-1, IL-2, IL-4, IL-8, IL-12, and IL-18, which are all immunomodulatory cytokines that play important roles in host immune responses against cancers. SETTING: Departments of gynecology and genetics in a medical center. PATIENT(S): Women were divided into: [1] a leiomyoma group (n = 162) and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Interleukin 1 Receptor Antagonist Protein
• Share to Interleukin-18