Article
Effect of differentiation on platelet-activating factor metabolism in HL-60 cells.
Journal of cell science - 1 Sept 1991
Stoll L L, Yerram N R, Spector A A
Abstract excerpt
The formation and metabolism of 1-O-alkyl-2-acetyl-sn-glycerol (AAG), a protein kinase C (PKC) activator formed from platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3- phosphocholine; PAF), was studied in HL-60 cells to determine whether differentiation may influence this process. HL-60 cells differentiated to macrophages (HL-60/M phi) with a phorbol ester convert added [3H]PAF to AAG; 22% of the...
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