Article
Suppressive roles of calreticulin in prostate cancer growth and metastasis.
The American journal of pathology - 1 Aug 2009
Alur Mahesh, Nguyen Minh M, Eggener Scott E, Jiang Feng, Dadras Soheil S, Stern Jeffrey, Kimm Simon, Roehl Kim, Kozlowski James, Pins Michael, Michalak Marek, Dhir Rajiv, Wang Zhou
Abstract excerpt
Calreticulin is an essential, multifunctional Ca(2+)-binding protein that participates in the regulation of intracellular Ca(2+) homeostasis, cell adhesion, and chaperoning. Calreticulin is abundantly expressed and regulated by androgens in prostate epithelial cells. Given the importance of both calreticulin in multiple essential cellular activities and androgens in prostate cancer, we investigated the...
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