Calreticulin: An Intracellular Ca++-Binding Protein Abundantly Expressed and Regulated by Androgen in Prostatic Epithelial Cells**This work was supported by Boehringer Ingelheim International GmbH, American Cancer Society, Illinois Division Grant 95–58, the Robert H. Lurie Cancer Center Grant 200, NCI 1R21 CA69851–01, a CaPCURE award, and NIH Grant R01-DK-51193.

Abstract excerpt

Calreticulin was identified in a screen for androgen-response genes in the rat ventral prostate. Northern blot and Western blot analyses in the rat model showed that both calreticulin messenger RNA and protein are down-regulated by castration and up-regulated by androgen replacement in the prostate. Northern blot analysis showed that calreticulin expression level in the prostate is much higher than that in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endoplasmic Reticulum Stress and Disease
• Share to Heat shock proteins research